Pertussis Immunity 5 Years After Booster Vaccination With Recombinant Pertussis Vaccines
Pertussis remains one of the least controlled vaccine-preventable diseases. Pertussis booster vaccines are associated with fast-waning immunity and offer only short-term protection.1 New vaccines providing longer-lasting protection are urgently needed.2
Pertussis toxin (PT), particularly if genetically detoxified (PTgen), represents the main antigen ensuring protection from pertussis disease.3 We previously demonstrated4 that recombinant acellular pertussis vaccines containing PTgen are more immunogenic and induce significantly higher PT-neutralizing antibody titers in adolescents than chemically inactivated tetanus-diphtheria-pertussis booster vaccines (Tdapchem). Follow-up studies have found that anti-PT antibodies remained greater than prevaccination levels 3 years after booster vaccination with recombinant pertussis vaccine, unlike with Tdapchem.5 We now report on antibody persistence 5 years after recombinant pertussis booster vaccination.
Read a full publication at JAMA